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KMID : 0350519960490031035
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Journal of Catholic Medical College
1996 Volume.49 No. 3 p.1035 ~ p.1044
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Effects of Sympathetic Innervation and Deferoxamine on Ischemia-Reperfusion Injury of Island Skin Flaps in the Rats.
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Abstract
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Adequate circulation is indispensable for flap survival, and prolonged ischemia in skin flaps causes tissue necrosis. But sometimes reperfusion followed by temporary ischemia causes tissue necrosis although circulation continues. The oxygen free
radicals have been known to play an important role in the detrimental effect on reperfused ischemic tissue, and the oxygen free radical scavenger has been used to defend against oxygen free radical toxicity. Besides, the nervous system has been
known to
have an important role in the regulation of the blood flow in skin and sympathetic denervation has been known to results in low viability of skin flap and to contribute to the production of oxygen free radicals.
@ES The results were as follows:
@EN 1. The viability of innervated flaps without treatment of deferoxamine after 4-hours and 6-hour ischemic periods (89.25±3.24%, 51.25±6.69%) was higher compared with the denervated group without treatment of deferoxamine (79.36±7.30%,
27.78±6.60%) (P<0.05).
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